Improved Cytokines IL-15 PRO

IL-15 Pro is an IL-15 with ultra high activity obtained through precise molecular design. In the production process, the problems of poor stability and easy formation of isomers of IL 15 have been solved. The purification process does not rely on reverse-phase chromatography, and it is more stable in solution. The affinity of IL-15 Pro for the IL-15 receptor is more than 100 times higher than that of the wild type, and its ability to promote the proliferation of NK cells is 20 times higher.

EXPERIMENTAL DATA

IL-15 Pro SDS PAGE and SEC HPLC Purity Analysis

• NR & R SDS-PAGE showed that the molecular weight of the protein was approximately 15 kDa (left), and no impurity protein was observed; SEC result showed high purity with no aggregates produced (right).

Comparison of the solubility between IL-15 Pro and IL-15

• SPR results showed that the Kd between human CD122 (IL-15R-beta) and IL-15 Pro is 0.51 nM

Proliferation Ability of IL-15 Pro on NK92 Cells and Comparison with Wild Type IL-15

PRODUCT FEATURES

• High activity,better cell stimulation effect

• Animal-free,reducing the risk of introducing exogenous viruses

• Less likely to form isomers,more stable for batch-to-batch use

• Both GMP grade and research grade are available

• High purity,stronger specificity

ORDERING INFORMATION